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. 2001 Oct;24(10):682-8.
doi: 10.1002/clc.4960241009.

Magnetocardiographic mapping of QRS fragmentation in patients with a history of malignant tachyarrhythmias

P Gödde  1 , R Agrawal, H P Müller, K Czerski, P Endt, U Steinhoff, M Oeff, H P Schultheiss, S Behrens
Affiliations

Magnetocardiographic mapping of QRS fragmentation in patients with a history of malignant tachyarrhythmias

P Gödde et al. Clin Cardiol. 2001 Oct.

Abstract

Background: The identification of patients at increased risk for ventricular tachycardia or ventricular fibrillation (VT/VF) and sudden cardiac death has consequences for therapeutic options and thus may reduce mortality in patients with coronary artery disease (CAD).

Hypothesis: We hypothesized that the intra-QRS fragmentation in magnetocardiographic recordings is increased in patients with CAD and with a history of VT/VF.

Methods: Multichannel magnetocardiography (MCG) was carried out in 34 healthy controls, 42 patients with CAD without a history of VT/VF, and 43 patients with CAD and with a history of VT/VF. The intra-QRS fragmentation was quantified by a new fragmentation score. Its spatial distribution was investigated using two-dimensional (2-D) contour maps according to the sensor position of the 49-channel magnetogradiometer.

Results: Patients with CAD and with a history of VT/VF had significantly increased QRS fragmentation compared with patients with CAD without VT/VF or controls (72.9+/-37.5, 48.5+/-14.3, and 42.5+/-7.8, respectively: p <0.05). The area of high fragmentation in 2-D contour maps was twice as large in patients with than in those without a history of VT/VF (represented by the number of MCG channels with high fragmentation: 26.3+/-15.5 vs. 12.4+/-9.9, p<0.0001). Patients prone to VT/VF could be identified with a sensitivity of 64% and a specificity of 90%.

Conclusion: In patients with CAD and with a history of VT/VF, intra-QRS fragmentation is increased and the area of high fragmentation in 2-D contour maps is enlarged. These findings may be helpful in identifying patients with CAD at risk for malignant tachyarrhythmias.

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References

    1. The Antiarrhythmics versus Implantable Defibrillators (AVID) Investigators : A comparison of antiarrhythmic drug therapy with implantable defibrillators in patients resuscitated from near‐fatal ventricular arrhythmias. N Engl J Med 1997; 337: 1576–1583 - PubMed
    1. Moss AJ, Hall WJ, Cannom DS, Daubert JP, Higgins SL, Klein H, Levine JH, Saksena S, Waldo AL, Wilber D, Brown MW, Heo M: Improved survival with an implanted defibrillator in patients with coronary disease at high risk for ventricular arrhythmia. Multi‐center Automatic Defibrillator Implantation Trial Investigators. N Engl J Med 1996; 335: 1933–1940 - PubMed
    1. de Bakker JM, van Capelle FJ, Janse MJ, Tasseron S, Vermeulen JT, de Jonge N, Lahpor JR: Slow conduction in the infarcted human heart. “Zigzag” course of activation. Circulation 1993; 88: 915–926 - PubMed
    1. Hood MA, Pogwizd SM, Peirick J, Cain ME: Contribution of myocardium responsible for ventricular tachycardia to abnormalities detected by analysis of signal‐averaged ECGs. Circulation 1992; 86: 1888–1901 - PubMed
    1. Buxton AE, Kleiman RB, Kindwall KE, Josephson ME: Endocardial mapping during sinus rhythm in patients with coronary artery disease and nonsustained ventricular tachycardia. Am J Cardiol 1993; 71: 695–698 - PubMed

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