Review
doi: 10.1016/s0092-8674(01)00518-9.
HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus
Affiliations
- PMID: 11595178
- DOI: 10.1016/s0092-8674(01)00518-9
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Review
HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus
Cell.
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Free article
Abstract
Hypoxia-inducible factor 1 (HIF-1) is a global regulator of cellular and systemic O(2) homeostasis in animals. A molecular basis for O(2)-regulated expression of the HIF-1 alpha subunit has now been determined, providing a mechanism for changes in gene expression in response to changes in cellular oxygenation.
Comment on
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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.Cell. 2001 Oct 5;107(1):43-54. doi: 10.1016/s0092-8674(01)00507-4. Cell. 2001. PMID: 11595184
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