doi: 10.1016/s0006-8993(01)02910-9.
Effects of serotonin synthesis blockade on interleukin-1 beta action in the brain of rats
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- PMID: 11595215
- DOI: 10.1016/s0006-8993(01)02910-9
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Effects of serotonin synthesis blockade on interleukin-1 beta action in the brain of rats
Brain Res.
.
Abstract
The ability of the brain serotonergic system to mediate the effects of interleukin-1beta (IL-1beta) was investigated. Intracerebroventricular administration of IL-1beta induced a significant pyrogenic reaction, depression in social behaviour, loss of body weight and reduced food intake in rats. Pre-treatment with p-chlorphenylalanine, an inhibitor of serotonin synthesis, blocked the IL-1beta-induced decrease in food intake and loss of body weight, but failed to alter the temperature increase and the decrease in communicative activity.
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