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Comparative Study
. 2001 Oct 30;111(2):151-5.
doi: 10.1016/s0165-0270(01)00450-2.

PEGylated polycyanoacrylate nanoparticles as vector for drug delivery in prion diseases

P Calvo  1 , B Gouritin, I Brigger, C Lasmezas, J Deslys, A Williams, J P Andreux, D Dormont, P Couvreur
Affiliations
Comparative Study

PEGylated polycyanoacrylate nanoparticles as vector for drug delivery in prion diseases

P Calvo et al. J Neurosci Methods. .

Abstract

PEGylated polymeric nanoparticles are hereby presented as a potential efficient drug carrier for the delivery of active therapeutic molecules in prion experimental diseases. Based on their blood long-circulating characteristics, these PEGylated particles made by the amphiphilic copolymer poly [methoxy poly(ethylene glycol) cyanoacrylate-co-hexadecyl cyanoacrylate] (PEG-PHDCA), showed comparatively conventional non-PEGylated nanoparticles, a higher uptake by the spleen and the brain which are both the target tissues of PrPres accumulation in scrapie infected animals.

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