doi: 10.1021/jm00244a018.
3-Hydroxymethyl-s-triazolo[3,4-a]phthalazine, a novel urinary hydralazine metabolite in man
- PMID: 1159684
- DOI: 10.1021/jm00244a018
Item in Clipboard
3-Hydroxymethyl-s-triazolo[3,4-a]phthalazine, a novel urinary hydralazine metabolite in man
J Med Chem.
1975 Oct.
Abstract
The elucidation of the structure of a new major metabolic product of hydralazine, 3-hydroxymethyl-s-triazolo[3,4-a]-phthalazine, is described. The structures of several other previously described metabolites of the drug, phthalazone, s-triazolo[3,4-a]phthalazine, and 3-methyl-s-triazolo[3,4-a]phthalazine, are confirmed. A metabolic pathway of hydralazine is also proposed.
Similar articles
-
Determination of hydralazine metabolites: 4-hydrazino-phthalazin-1-one and n-acetylhydrazinophthalazin-1-one by gas chromatography and s-triazolo[3,4-alpha]phthalazine and phthalazinone by high-performance liquid chromatography.J Chromatogr. 1980 Aug 8;183(2):167-73. doi: 10.1016/s0378-4347(00)81690-4. J Chromatogr. 1980. PMID: 7400275
-
Identification of 3-methyl-s-triazolo(3,4-alphathalazine, a human hydralazine metabolite, by gas chromatography-mass spectrometry.Arzneimittelforschung. 1973 Aug;23(8):1028-9. Arzneimittelforschung. 1973. PMID: 4801020 No abstract available.
-
Studies on the in vivo metabolism of hydralazine in the rat.Drug Metab Dispos. 1983 May-Jun;11(3):184-9. Drug Metab Dispos. 1983. PMID: 6135573
-
Identification of the decomposition products of hydralazine hydrazones with three endogenous ketones and kinetic study of the formation of 3-methyl-s-triazolo[3,4,a]phthalazine from hydralazine and pyruvic acid].Chem Pharm Bull (Tokyo). 1980 Nov;28(11):3407-11. doi: 10.1248/cpb.28.3407. Chem Pharm Bull (Tokyo). 1980. PMID: 7214613 No abstract available.
-
Synthesis and biological activity of structurally diverse phthalazine derivatives: A systematic review.Bioorg Med Chem. 2019 Sep 15;27(18):3979-3997. doi: 10.1016/j.bmc.2019.07.050. Epub 2019 Aug 1. Bioorg Med Chem. 2019. PMID: 31401008
Cited by
-
Clinical pharmacokinetics of hydralazine.Clin Pharmacokinet. 1982 May-Jun;7(3):185-205. doi: 10.2165/00003088-198207030-00001. Clin Pharmacokinet. 1982. PMID: 7047041 Review. No abstract available.
-
Studies on hydralazine. II. Elimination rate and steady-state concentration in patients with impaired renal function.Eur J Clin Pharmacol. 1976 Sep 30;10(5):311-7. doi: 10.1007/BF00565619. Eur J Clin Pharmacol. 1976. PMID: 976304
-
Effect of N-Acetyltransferase 2 Genotype on the Pharmacokinetics of Hydralazine During Pregnancy.J Clin Pharmacol. 2019 Dec;59(12):1678-1689. doi: 10.1002/jcph.1477. Epub 2019 Jun 30. J Clin Pharmacol. 2019. PMID: 31257615 Free PMC article.
-
Studies on hydralazine. III. Bioavailability of hydralazine in man.Eur J Clin Pharmacol. 1976;10(6):395-401. doi: 10.1007/BF00563075. Eur J Clin Pharmacol. 1976. PMID: 1001354
-
Clinical pharmacokinetics of hydrallazine.Clin Pharmacokinet. 1977 Sep-Oct;2(5):317-29. doi: 10.2165/00003088-197702050-00001. Clin Pharmacokinet. 1977. PMID: 913002 No abstract available.