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. 2001 Nov;25(11):927-32.
doi: 10.1016/s0145-2126(01)00049-2.

Peripheral blood CD38 expression predicts survival in B-cell chronic lymphocytic leukemia

F Morabito  1 , M Mangiola, B Oliva, C Stelitano, V Callea, S Deaglio, P Iacopino, M Brugiatelli, F Malavasi
Affiliations

Peripheral blood CD38 expression predicts survival in B-cell chronic lymphocytic leukemia

F Morabito et al. Leuk Res. 2001 Nov.

Abstract

CD38 expression was investigated in 161 untreated patients with B-cell chronic lymphocytic leukemia (B-CLL). A score system, devised ad hoc by integrating the percentage and the mean fluorescence intensity (MFI) values of CD38(+) cells, indicated that B-CLL patients with a CD38 score < or =3 are characterized by a significantly longer survival compared to those with a CD38 score >3 (P=0.0026). Thirty-seven percent of patients with a CD38 score < or =3 and 58% of those with a score >3 were dead at 10 years. Multivariate analysis indicates that only the CD38 score successfully predicts survival (P=0.0028), with an estimated 3.8-fold greater risk of death for those cases with CD38 score >3.

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