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Review
. 2001 Sep 15;92(6 Suppl):1678-83.
doi: 10.1002/1097-0142(20010915)92:6+<1678::aid-cncr1496>3.0.co;2-r.

The biologic basis of fatigue

H B Gutstein  1
Affiliations
Review

The biologic basis of fatigue

H B Gutstein. Cancer. .

Abstract

In spite of many remarkable advances in our understanding of the mechanisms of cancer biology, very little attention has been directed toward mechanisms underlying cancer-induced symptoms. Although fatigue is a widely prevalent complication of cancer, there is a paucity of both basic and clinical research in this area. This article details our current knowledge of mechanisms causing cancer-related fatigue and briefly discusses currently available therapeutic options. A framework for addressing gaps in our knowledge and recommendations for future research directions are proposed.

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