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. 1975 Sep;16(3):712-9.
doi: 10.1128/JVI.16.3.712-719.1975.

Study of the fine structure of adeno-associated virus DNA with bacterial restriction endonucleases

K I Berns, J Kort, K H Fife, E W Grogan, I Spear

Study of the fine structure of adeno-associated virus DNA with bacterial restriction endonucleases

K I Berns et al. J Virol. 1975 Sep.

Abstract

A physical map of the adeno-associated virus type 2 genome has been constructed on the basis of the five fragments produced by the restriction endonucleases HindII + III from Hemophilus influenzae. There are three endo R-HindII cleavage sites and one endo R-HindIII site. Evidence has been obtained to support the existence of two nucleotide sequence permutations in adeno-associated virus DNA, the start points of which have been estimated to be separated by 1% of the genome. The three cleavage fragments produced by endo R-Eco RI have been ordered and oriented with respect to the endo R-HindII + III cleavage map.

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References

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