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. 2001 Oct 2;165(7):908-9.

Statins and the prevention of dementia

U N Das  1
Affiliations

Statins and the prevention of dementia

U N Das. CMAJ. .
No abstract available

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Figures

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Fig. 1: The possible relation between statins and endothelial nitric oxide (eNO), bone morphogenetic proteins (BMPs), proinflammatory cytokines, Alzheimer's disease and other diseases. TNF-α = tumour necrosis factor-α, IL-6 = interleukin-6, GTPase = guanosine triphosphatase, CHD = coronary heart disease.
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References

    1. Jick H, Zornberg GL, Jick SS, Seshadri S, Drachman DA. Statins and the risk of dementia. Lancet 2000;356(9242):1627-31. - PubMed
    1. Wolozin B, Kellman W, Rousseau P, Celesia CG, Siegel G. Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Arch Neurol 2000;57:1439-43. - PubMed
    1. Lopez-Coviella I, Berse B, Krauss R, Thies RS, Blusztajn JK. Induction and maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP-9. Science 2000;289(5477):313-6. - PubMed
    1. Das UN. Essential fatty acids and osteoporosis. Nutrition 2000;16(15):386-90. - PubMed
    1. Lahera V, Khraibi AA, Romero JC. Sulfhydryl group donors potentiate the hypotensive effect of acetylcholine in rats. Hypertension 1993;22:156-60. - PubMed

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