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. 2001;43(8):797-802.

[Phospholipase C negatively regulates tyrosine phosphorylation of EGF receptor in A-431 cells]

[Article in Russian]
A L Evdonin  1 , A N Leonov, N V Tsupkina, N D Medvedeva
Affiliations
  • PMID: 11601396

[Phospholipase C negatively regulates tyrosine phosphorylation of EGF receptor in A-431 cells]

[Article in Russian]
A L Evdonin et al. Tsitologiia. 2001.

Abstract

It is known that EGF induces tyrosine phosphorylation and internalization of the EGF receptor in A-431 cells. U73122, an inhibitor of phospholipase C, induces tyrosine phosphorylation of the EGF receptor and its association with phospholipase C still in nonstimulated cells. In U73122 treated cells EGF exerted no effect on these processes. Receptor-mediated endocytosis was not observed in A-431 cells treated with U73122. The reorganization of actin cytoskeleton was detected in U73122 cells.

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