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Clinical Trial
. 2001 Nov;99(1):33-7.
doi: 10.1016/s0301-2115(01)00354-2.

Meconium-stained amniotic fluid in labor: a randomized trial of prophylactic amniofusion

A Puertas  1 , M Paz Carrillo, L Moltó, M Alvarez, S Sedeño, J A Miranda
Affiliations
Clinical Trial

Meconium-stained amniotic fluid in labor: a randomized trial of prophylactic amniofusion

A Puertas et al. Eur J Obstet Gynecol Reprod Biol. 2001 Nov.

Abstract

Objectives: To investigate the effect of amnioinfusion in women with meconium-stained amniotic fluid on the rate of cesarian sections and on neonatal morbidity.

Study design: A randomized controlled trial. A total of 206 women with meconium-stained amniotic fluid were assigned to receive amnioinfusion via two-way catheter or no amnioinfusion (control group). The catheter was inserted and other treatment was the same in both groups.

Results: Amnioinfusion decreased the rate of cesarian sections for fetal distress (RR 0.23, 95% CI 0.07-0.79) and increased mean pH at birth (7.24+/-0.1 versus 7.21+/-0.1, P<0.05). It also decreased the frequency of variable fetal heart rate decelerations (RR 0.74, 95% CI 0.59-0.92), and of meconium below the vocal cords in neonates (RR 0.37, 95% CI 0.19-0.69).

Conclusions: Amnioinfusion improves the neonatal outcome and reduces the frequency of cesarian sections.

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