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Review
. 2001 Sep;8(5):270-6.
doi: 10.1097/00062752-200109000-00002.

Mechanisms of platelet aggregation

B Savage  1 , M Cattaneo, Z M Ruggeri
Affiliations
Review

Mechanisms of platelet aggregation

B Savage et al. Curr Opin Hematol. 2001 Sep.

Abstract

Platelet aggregation is initiated by receptor activation coupled to intracellular signaling leading to activation of integrin alphaIIbbeta3. Recent advances in the study of platelet receptors for collagen, von Willebrand factor, thrombin, and adenosine diphosphate are providing new insights into the mechanisms of platelet aggregation.

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