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. 2001 Oct;49(10):1366-7.
doi: 10.1248/cpb.49.1366.

Biosynthetic study of amphidinolide B

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Free article

Biosynthetic study of amphidinolide B

M Tsuda et al. Chem Pharm Bull (Tokyo). 2001 Oct.
Free article

Abstract

The biosynthetic origins of amphidinoide B (1) were investigated on the basis of 13C-NMR data of 13C-enriched samples obtained by feeding experiments with [1-(13)C], [2-(13)C], and [1,2-(13)C2] sodium acetates in cultures of a dinoflagellate Amphidinium sp. These incorporation patterns suggested that 1 was generated from three successive polyketide chains, an isolated C1 unit from C-2 of acetates, six branched C1 units from C-2 of acetates, and an "m-m" and an "m-m-m" unit derived only from C-2 of acetates. The labeling patterns of amphidinolide B (1) were different from those of amphidinolide H (2), a 26-membered macrolide closely related to 1.

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