Review
doi: 10.1067/mjd.2001.113715.
Retinoic acid metabolism
Affiliations
- PMID: 11606945
- DOI: 10.1067/mjd.2001.113715
Item in Clipboard
Review
Retinoic acid metabolism
J Am Acad Dermatol.
2001 Nov.
Abstract
The tissue distribution of retinoic acid (RA) throughout development is highly restricted, defined by the expression patterns of enzymes involved in RA synthesis and catabolism. Presented is a summary of recent research that examines the role of some of the enzymes involved in RA distribution, particularly those involved in RA catabolism (P450RAI). These latter enzymes protect against premature exposure to RA, and the implications of these findings are discussed.
Similar articles
-
Cytochrome P450RAI(CYP26) promoter: a distinct composite retinoic acid response element underlies the complex regulation of retinoic acid metabolism.Mol Endocrinol. 2000 Sep;14(9):1483-97. doi: 10.1210/mend.14.9.0518. Mol Endocrinol. 2000. PMID: 10976925
-
Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism.Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6403-8. doi: 10.1073/pnas.120161397. Proc Natl Acad Sci U S A. 2000. PMID: 10823918 Free PMC article.
-
Retinol conversion to retinoic acid is impaired in breast cancer cell lines relative to normal cells.J Cell Physiol. 2000 Nov;185(2):302-9. doi: 10.1002/1097-4652(200011)185:2<302::AID-JCP15>3.0.CO;2-#. J Cell Physiol. 2000. PMID: 11025452
-
The cloning and characterization of a novel cytochrome P450 family, CYP26, with specificity toward retinoic acid.Nutr Rev. 1998 Mar;56(3):84-5. doi: 10.1111/j.1753-4887.1998.tb01699.x. Nutr Rev. 1998. PMID: 9564181 Review.
-
The role of CYP26 enzymes in defining appropriate retinoic acid exposure during embryogenesis.Birth Defects Res A Clin Mol Teratol. 2010 Oct;88(10):883-94. doi: 10.1002/bdra.20709. Birth Defects Res A Clin Mol Teratol. 2010. PMID: 20842651 Review.
Cited by
-
Enhanced expression of retinoic acid-metabolizing enzyme CYP26A1 in sunlight-damaged human skin.Med Mol Morphol. 2011 Dec;44(4):200-6. doi: 10.1007/s00795-010-0528-x. Epub 2011 Dec 17. Med Mol Morphol. 2011. PMID: 22179182
-
Hepatic metabolism of retinoids and disease associations.Biochim Biophys Acta. 2012 Jan;1821(1):124-36. doi: 10.1016/j.bbalip.2011.06.023. Epub 2011 Jul 1. Biochim Biophys Acta. 2012. PMID: 21763780 Free PMC article. Review.
-
From carrot to clinic: an overview of the retinoic acid signaling pathway.Cell Mol Life Sci. 2010 May;67(9):1423-45. doi: 10.1007/s00018-010-0268-z. Epub 2010 Feb 7. Cell Mol Life Sci. 2010. PMID: 20140749 Free PMC article. Review.
-
9-cis β-Carotene Increased Cholesterol Efflux to HDL in Macrophages.Nutrients. 2016 Jul 19;8(7):435. doi: 10.3390/nu8070435. Nutrients. 2016. PMID: 27447665 Free PMC article.
-
Retinoic acid 4-hydroxylase inducibility and clinical response to isotretinoin in patients with acne.J Am Acad Dermatol. 2009 Aug;61(2):252-8. doi: 10.1016/j.jaad.2009.03.013. Epub 2009 Jun 13. J Am Acad Dermatol. 2009. PMID: 19525031 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
