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. 1975 Mar;160(2):108-29.

Investigations on the carcinogenic burden by air pollution in man. XII. Early pathological alterations of the bronchial epithelium in syrian golden hamsters after intratracheal instillation of benzo(a)pyrene

H Reznik-Schüller, U Mohr
  • PMID: 1163169

Investigations on the carcinogenic burden by air pollution in man. XII. Early pathological alterations of the bronchial epithelium in syrian golden hamsters after intratracheal instillation of benzo(a)pyrene

H Reznik-Schüller et al. Zentralbl Bakteriol Orig B. 1975 Mar.

Abstract

The ultrastructural alterations occurring in the bronchial epithelium of Syrian golden hamsters treated once weekly for life with 0.63 mg BP were examined during the first 20 weeks of treatment. It was demonstrated that epithelial cells penetrated the basement membrane thus finally forming small bronchogenic tumours (adenomata) composed of ciliated, nonciliated and a few basal cells. No squamous metaplasis occurred.

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