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Comparative Study
. 1975 Sep;35(3):153-8.

Tryptophane metabolism in bronchial asthma

P J Collipp, S Y Chen, R K Sharma, V Balachandar, V T Maddaiah
  • PMID: 1163858
Comparative Study

Tryptophane metabolism in bronchial asthma

P J Collipp et al. Ann Allergy. 1975 Sep.

Abstract

Seventeen out of 21 children with severe asthma had an abnormal increase in urinary Kynurenic (KA) and Xanthurenic (XA) acid following oral tryptophane administration. In a second study 11 asthmatic children had significantly greater increases in XA and KA than nine normal healthy children. A micro-assay of KA and XA by column chromatography was performed. The data suggest the presence of a partial block in the metabolism of tryptophane in some children with bronchial asthma.

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