[Effect of antihypertensive agents on the in vitro biosynthesis of prostaglandin E and F2 alpha in the rabbit kidney medulla]
[Article in
German]
- PMID: 1164100
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[Effect of antihypertensive agents on the in vitro biosynthesis of prostaglandin E and F2 alpha in the rabbit kidney medulla]
[Article in
German]
Arch Int Pharmacodyn Ther.
1975 Jul.
Abstract
This report describes the influence of antihypertensive drugs on the biosynthesis of prostaglandins from endogenous precursors in the homogenates of rabbit kidney medulla. Dihydralazine and reserpine inhibited, alpha-methyldopa on the contrary stimulated the in vitro biosynthesis of prostaglandins E and F2alpha. Clonidin was without effect. The effects of noradrenaline and indomethacine as standard substances were determined.
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