Inhibition of the sympathetic nervous system by dopamine
- PMID: 1164103
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Inhibition of the sympathetic nervous system by dopamine
Arch Int Pharmacodyn Ther.
1975 Jul.
Abstract
If the right postganglionic cardioaccelerator nerves of cats are stimulated (2 Hz), dopamine, in the presence of cocaine, inhibits transmission. This inhibitory response is prevented by low doses of haloperidol. Phentolamine produces some antagonism and phenoxy-benzamine produces no antagonism to the dopamine-induced inhibition. It is postulated that dopamine receptors on the adrenergic nerve terminals modulate norepinephrine release.
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