Antagonism of arachidonic acid hydroperoxide on isolated gastrointestinal tissues as a measure of the inhibition of prostaglandin biosynthesis
- PMID: 11650
Item in Clipboard
Antagonism of arachidonic acid hydroperoxide on isolated gastrointestinal tissues as a measure of the inhibition of prostaglandin biosynthesis
Adv Prostaglandin Thromboxane Res.
1976.
Abstract
Arachidonic acid hydroperoxide (AAP)-induced contractions of the isolated guinea pig ileum and rat stomach fundus are inhibited by suprofen [alpha-methyl-4-(2-thienylcarbonyl) benzeneacetic acid], indomethacin, phenylbutazone, and acetylsalicyclic acid in descending order of activity. This effect is highly specific, since prostaglandins (PG) and various agonists of gastrointestinal smooth muscle are not, or only weakly antagonized by these four compounds, whereas various compounds, including narcotic analgesics, are inactive versus AAP. The antagonism of AAP-induced contractions of the isolated rat stomach fundus is a valuable test system for inhibitors of PG biosynthesis.
Similar articles
-
Inhibition by suprofen and other non-narcotic analgesic drugs of the effects of prostaglandin precursor on isolated tissues and platelets.Arch Int Pharmacodyn Ther. 1976 Apr;220(2):297-310. Arch Int Pharmacodyn Ther. 1976. PMID: 8022
-
Suprofen, a potent antagonist of acetic acid-induced writhing in rats.Arzneimittelforschung. 1975 Oct;25(10):1505-9. Arzneimittelforschung. 1975. PMID: 1243029
-
Contractile responses of the guinea-pig trachea in vitro: modification by prostaglandin synthesis-inhibiting drugs.J Pharmacol Exp Ther. 1975 Sep;194(3):554-64. J Pharmacol Exp Ther. 1975. PMID: 1159632
-
Suprofen: the pharmacology and clinical efficacy of a new non-narcotic peripheral analgesic.Clin Rheum Dis. 1984 Aug;10(2):353-68. Clin Rheum Dis. 1984. PMID: 6439459 Review.
-
Mode of action of aspirin-like drugs.Adv Intern Med. 1979;24:1-22. Adv Intern Med. 1979. PMID: 371357 Review. No abstract available.
MeSH terms
Substances
LinkOut - more resources
Miscellaneous