Comparative Study
Problems and solutions to single-dose testing of analgesics: comparison of propoxyphene, codeine, and fenoprofen
- PMID: 1165140
Item in Clipboard
Comparative Study
Problems and solutions to single-dose testing of analgesics: comparison of propoxyphene, codeine, and fenoprofen
Int J Clin Pharmacol Biopharm.
1975 Jul.
Abstract
Discrepancies exist between reports arising from single-dose and multiple-dose studies intended to compare the efficacy of oral analgesics. D Differences in the pharmacokinetic characteristics of these drugs account for much of the discord. Codeine and fenoprofen rapidly achieve their ultimate plasma equilibrium levels (on a q. 6h. schedule), whereas, propoxyphene requires a longer period, doubtless due to its longer half-life and proportionately smaller maintenance dose. If the drugs are not to be compared during the steady state, then administration of appropriate loading doses permits satisfactory single dose comparisons at steady-state concentrations.
Similar articles
-
Dose response to fenoprofen in an antipyretic study of fenoprofen and propoxyphene.J Med. 1977;8(1):27-34. J Med. 1977. PMID: 327002 Clinical Trial.
-
Analgesia, plasma levels, and dosage of propoxyphene.Int J Clin Pharmacol Biopharm. 1976 Apr;13(3):177-81. Int J Clin Pharmacol Biopharm. 1976. PMID: 950259
-
A multicenter study for analgesia involving fenoprofen, propoxyphene [alone or in combination] with placebo and aspirin controls in postpartum pain.J Med. 1979;10(1-2):65-98. J Med. 1979. PMID: 290726 Clinical Trial.
-
Dose response to fenoprofen calcium using placebo and codeine as controls.J Med. 1985;16(4):439-52. J Med. 1985. PMID: 3913726 Clinical Trial.
-
The metabolic chiral inversion of 2-arylpropionic acids--a novel route with pharmacological consequences.J Pharm Pharmacol. 1983 Nov;35(11):693-704. doi: 10.1111/j.2042-7158.1983.tb02874.x. J Pharm Pharmacol. 1983. PMID: 6139449 Review. No abstract available.
Cited by
-
Effects of a mu-opioid receptor agonist (codeine phosphate) on visuo-motor coordination and dynamic visual acuity in man.Br J Clin Pharmacol. 1986 Nov;22(5):507-12. doi: 10.1111/j.1365-2125.1986.tb02928.x. Br J Clin Pharmacol. 1986. PMID: 3024689 Free PMC article. Clinical Trial.
-
Dextropropoxyphene overdosage. Pharmacological considerations and clinical management.Drugs. 1983 Jul;26(1):70-9. doi: 10.2165/00003495-198326010-00004. Drugs. 1983. PMID: 6349964 Review.
-
Dextropropoxyphene overdose. Epidemiology, clinical presentation and management.Med Toxicol Adverse Drug Exp. 1987 Nov-Dec;2(6):430-44. doi: 10.1007/BF03259877. Med Toxicol Adverse Drug Exp. 1987. PMID: 3323775 Review.
-
Single- and multiple-dose pharmacokinetics of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (MNK-155) compared with immediate-release hydrocodone bitartrate/ibuprofen and immediate-release tramadol HCl/acetaminophen.J Pain Res. 2015 Sep 30;8:647-56. doi: 10.2147/JPR.S83416. eCollection 2015. J Pain Res. 2015. PMID: 26508885 Free PMC article.