Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975 Oct;16(4):767-74.
doi: 10.1128/JVI.16.4.767-774.1975.

Adenovirus type 2 DNA replication. II. Termini of DNA replication

R Schilling, B Weingärtner, E L Winnacker

Adenovirus type 2 DNA replication. II. Termini of DNA replication

R Schilling et al. J Virol. 1975 Oct.

Abstract

Complete, mature adenovirus type 2 DNA molecules were isolated from virus-infected HeLa cells, pulse-labeled at 20 h postinfection in [3H]thymidine pulses shorter than the time necessary for one round of viral DNA replication. After digestion with the restriction endonucleases Eco RI, Hpa I, and Hind III, a temporal order of synthesis of different regions of the viral genome was established from the relative specific radioactivities in the restriction enzyme fragments. A comparison with the physical order of these fragments revealed the existence of two termini of DNA replication towards both the molecular right and left ends, respectively, of the viral chromosome.

PubMed Disclaimer

References

    1. Nat New Biol. 1972 Sep 13;239(89):47-9 - PubMed
    1. Virology. 1973 Nov;56(1):54-69 - PubMed
    1. Virology. 1973 Jan;51(1):11-23 - PubMed
    1. J Mol Biol. 1970 Jul 28;51(2):379-91 - PubMed
    1. Cold Spring Harb Symp Quant Biol. 1975;39 Pt 1:547-50 - PubMed

LinkOut - more resources