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. 1975 Sep;149(4):1026-8.
doi: 10.3181/00379727-149-38949.

Suppression of lymphocyte transformation by 16, (16) dimethyl prostaglandin E2 and unsaturated fatty acids

A A Mihas, R G Gibson, B I Hirschowitz

Suppression of lymphocyte transformation by 16, (16) dimethyl prostaglandin E2 and unsaturated fatty acids

A A Mihas et al. Proc Soc Exp Biol Med. 1975 Sep.

Abstract

A new synthetic prostaglandin (16, 16-PGE2) and unsaturated fatty acids have been shown to inhibit the incorporation of [3H]thymidine in the lymphocyte transformation reaction in response to phytohemagglutinin (PHA). This inhibition was not due to toxicity of these substances, for the lymphocytes remained intact and capable of excluding trypan blue.

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