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. 1975 Sep;149(4):1052-4.
doi: 10.3181/00379727-149-38956.

Hydroxyurea-induced erythroid differentiation

N J Rencricca, B S Morse, F C Monette, D Howard, F Stohlman Jr

Hydroxyurea-induced erythroid differentiation

N J Rencricca et al. Proc Soc Exp Biol Med. 1975 Sep.

Abstract

Hydroxyurea, a cytotoxic agent which destroys cells in DNA synthesis, has been shown to evoke the differentiation of a small number of hemopoietic precursor cells in the erythroid series of erythropoietically suppressed hypertransfused mice. This effect does not appear to be mediated by erythropoietin (EP) since the simultaneous injection of anti-EP did not alter this response.

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