doi: 10.1021/jo971556g.
Salicylihalamides A and B, Novel Cytotoxic Macrolides from the Marine Sponge Haliclona sp
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- PMID: 11671930
- DOI: 10.1021/jo971556g
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Salicylihalamides A and B, Novel Cytotoxic Macrolides from the Marine Sponge Haliclona sp
J Org Chem.
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Abstract
Two novel, highly potent, cytotoxic macrolides, salicylihalamides A (1) and B (2), were isolated from the sponge Haliclona sp. This new macrolide class incorporates salicylic acid, a 12-membered lactone ring, and an enamide side chain. COMPARE pattern-recognition analyses of the NCI 60-cell mean graph screening profiles of 1 did not reveal any significant correlations to the profiles of known antitumor compounds in the NCI's "standard agent database", thus supporting the conclusion that the salicylihalamides represent a potentially important new class for antitumor lead optimization and in vivo investigations.
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