Sleeping with the enemy--endogenous superantigens in humans
- PMID: 11672533
- DOI: 10.1016/s1074-7613(01)00211-4
Sleeping with the enemy--endogenous superantigens in humans
Abstract
We usually think of superantigens (SAg) as dangerous toxins that may cause toxic shock syndrome and death. Now, based on two papers in this issue of Immunity, it seems that we all have SAg genes within us, lying dormant and waiting to be activated under special circumstances.
Comment on
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Epstein-Barr virus transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen.Immunity. 2001 Oct;15(4):579-89. doi: 10.1016/s1074-7613(01)00210-2. Immunity. 2001. PMID: 11672540
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Interferon-alpha-induced endogenous superantigen. a model linking environment and autoimmunity.Immunity. 2001 Oct;15(4):591-601. doi: 10.1016/s1074-7613(01)00212-6. Immunity. 2001. PMID: 11672541
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