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. 2001 Oct;15(4):569-78.
doi: 10.1016/s1074-7613(01)00206-0.

WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection

H Yoshida  1 , S Hamano, G Senaldi, T Covey, R Faggioni, S Mu, M Xia, A C Wakeham, H Nishina, J Potter, C J Saris, T W Mak
Affiliations
Free article

WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection

H Yoshida et al. Immunity. 2001 Oct.
Free article

Abstract

WSX-1 is a class I cytokine receptor with homology to the IL-12 receptors. The physiological role of WSX-1, which is expressed mainly in T cells, was investigated in gene-targeted WSX-1-deficient mice. IFN-gamma production was reduced in isolated WSX-1(-/-) T cells subjected to primary stimulation in vitro to induce Th1 differentiation but was normal in fully differentiated and activated WSX-1(-/-) Th1 cells that had received secondary stimulation. WSX-1(-/-) mice were remarkably susceptible to Leishmania major infection, showing impaired IFN-gamma production early in the infection. However, IFN-gamma production during the later phases of the infection was not impaired in the knockout. WSX-1(-/-) mice also showed poorly differentiated granulomas with dispersed accumulations of mononuclear cells when infected with bacillus Calmette-Guerin (BCG). Thus, WSX-1 is essential for the initial mounting of Th1 responses but dispensable for their maintenance.

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