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. 1999 Feb 5;64(3):731-735.
doi: 10.1021/jo981034g.

Axinellamines A-D, Novel Imidazo-Azolo-Imidazole Alkaloids from the Australian Marine Sponge Axinella sp

Sylvia Urban  1 , Priscila de Almeida Leone, Anthony R. Carroll, Gregory A. Fechner, Jill Smith, John N. A. Hooper, Ronald J. Quinn
Affiliations

Axinellamines A-D, Novel Imidazo-Azolo-Imidazole Alkaloids from the Australian Marine Sponge Axinella sp

Sylvia Urban et al. J Org Chem. .

Abstract

Four imidazo-azolo-imidazole alkaloids, axinellamines A-D, have been isolated from an Australian marine sponge, Axinella sp. (order: Halichondrida: family: Axinellidae). These compounds contain a unique perhydrocyclopenta-imidazo-azolo-imidazole carbon skeleton. Three of these compounds had bactericidal activity against Helicobacter pylori at 1000 &mgr;M.

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