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. 1975 Jan 17;187(4172):169-71.
doi: 10.1126/science.1167425.

Daily rhythm in human urinary melatonin

H J Lynch, R J Wurtman, M A Moskowitz, M C Archer, M H Ho

Daily rhythm in human urinary melatonin

H J Lynch et al. Science. .

Abstract

The melatonin in urine samples from six healthy adult volunteers was concentrated on Amberlite XAD-2 resin, eluted with organic solvents, and quantitated by use of a bioassay technique (the dermal melanaphore response of larval anurans to melatonin in their bathing medium). The melatonin content of samples collected between 11 p.m. and 7 a.m. was, in each case, several times higher than that of samples collected between 7 a.m. and 3 p.m. or between 3 p.m. and 11 p.m.

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