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. 1999 Sep 3;64(18):6702-6705.
doi: 10.1021/jo990454i.

Synthesis of Aryl-Substituted Piperidines by Superacid Activation of Piperidones

Douglas A. Klumpp  1 , Manuel Garza, Andre Jones, Saray Mendoza
Affiliations

Synthesis of Aryl-Substituted Piperidines by Superacid Activation of Piperidones

Douglas A. Klumpp et al. J Org Chem. .

Abstract

Diarylpiperidines (8-12) may be prepared in good to excellent yields (80-99%) by the reaction of piperidones (3d-h) with benzene and the Bronsted superacid, trifluoromethanesulfonic acid (CF(3)SO(3)H, TfOH). Tropinone (6) and quinuclidone (7) also react in good yields with benzene in TfOH to give the condensation products (13 and 14). Ketal and acetal derivatives also give condensation products (8 and 24) upon reaction with C(6)H(6) in TfOH. The conversion of 3g to 11 is sensitive to both acid quantity and acid strength; a mechanism is proposed for the conversion that invokes dicationic intermediates.

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