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. 1975 Feb;28(2):102-11.
doi: 10.7164/antibiotics.28.102.

New azasteroidal antifungal antibiotics from Geotrichum flavo-brunneum. II. Isolation and characterization

K H Michel, R L Hamill, S H Larsen, R H Williams
Free article

New azasteroidal antifungal antibiotics from Geotrichum flavo-brunneum. II. Isolation and characterization

K H Michel et al. J Antibiot (Tokyo). 1975 Feb.
Free article

Abstract

A novel group of antibiotics, comprising microbiologically-active structurally-related factors A25822A, B, D, H, L, M and N, produced by culturing Geotrichum flavo-brunneum NRRL 3862 under submerged aerobic fermentation conditions was isolated by extraction. The individual factors were separated and purified by chromatography and crystallization. The major factor, A25822B, a 15-aza-24-methylene-D-homocholestadiene is a white crystalline compound, C25H45NO. The antibiotics are highly active against fungi and marginally active against bacteria.

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