Comment
doi: 10.1073/pnas.231481398.
Crosstalk of the group IIa and IIb metals calcium and zinc in cellular signaling
Affiliations
- PMID: 11675482
- PMCID: PMC60047
- DOI: 10.1073/pnas.231481398
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Comment
Crosstalk of the group IIa and IIb metals calcium and zinc in cellular signaling
Proc Natl Acad Sci U S A.
.
No abstract available
Figures
The effect of extracellular zinc on cellular calcium signaling. (Pathway A), Mechanism proposed by Hershfinkel et al. (5). (Pathway B), Alternative pathway through control of protein tyrosine kinases and phosphatases by zinc. Both pathways lead to phospholipase C activation, mobilization of intracellular calcium, and activation of the Na+/H+ exchanger. Zinc exporters and importers control the transport of zinc between the extracellular space and the cytoplasm.
Comment on
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Thiolate ligands in metallothionein confer redox activity on zinc clusters.Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3478-82. doi: 10.1073/pnas.95.7.3478. Proc Natl Acad Sci U S A. 1998. PMID: 9520391 Free PMC article.
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Inhibitory sites in enzymes: zinc removal and reactivation by thionein.Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):1936-40. doi: 10.1073/pnas.96.5.1936. Proc Natl Acad Sci U S A. 1999. PMID: 10051573 Free PMC article.
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Differential fluorescence labeling of cysteinyl clusters uncovers high tissue levels of thionein.Proc Natl Acad Sci U S A. 2001 May 8;98(10):5556-9. doi: 10.1073/pnas.101123298. Epub 2001 May 1. Proc Natl Acad Sci U S A. 2001. PMID: 11331777 Free PMC article.
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A zinc-sensing receptor triggers the release of intracellular Ca2+ and regulates ion transport.Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11749-54. doi: 10.1073/pnas.201193398. Proc Natl Acad Sci U S A. 2001. PMID: 11573009 Free PMC article.
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