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Comment
. 2001 Oct 23;98(22):12331-3.
doi: 10.1073/pnas.231485898.

How do tumors make ends meet?

C Lengauer  1
Affiliations
Comment

How do tumors make ends meet?

C Lengauer. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Anaphase bridges. (A and B) Images from the late 1930s show Indian corn chromosomes that have duplicated and separated. A “chromatin bridge” connects one chromosome from the upper set to one from the lower set (ref. ; reproduced courtesy of B. McClintock and the American Philosophical Society Library). (C) Chromosome spread prepared from pistils of a late-generation telomerase-deficient mustard weed mutant. End-to-end chromosome fusions are visible in anaphase. Chromosomes are stained with 4′,6′-diamidino-2-phenylindole (ref. ; courtesy of K. Riha and D. E. Shippen, Texas A&M University, College Station, TX). [Reproduced with permission from ref. (Copyright 2001, AAAS).] (D) Anaphase bridges in the moderately differentiated human pancreatic carcinoma LPC6 (ref. ; courtesy of D. Gisselsson, University Hospital, Lund, Sweden). (E) Anaphase bridges in the oral carcinoma UPCI: SCC131. Centromeres (red) are trapped in the forming midbody as this late telophase cell divides. Immunolabeling with tubulin antibodies (yellow), chromosomes stained with 4′,6′-diamidino-2-phenylindole (blue; courtesy of W. S. Saunders and S. M. Gollin, University of Pittsburgh and the University of Pittsburgh Cancer Institute, Pittsburgh, PA). [Reproduced with permission from ref. (Copyright 2000, National Academy of Sciences).]
See this image and copyright information in PMC

Comment on

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