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. 1975 Mar;114(3):1047-51.

Polymorphonuclear leukocytes in antibody-dependent cellular cytotoxicity

R P Gale, J Zighelboim
  • PMID: 1167565

Polymorphonuclear leukocytes in antibody-dependent cellular cytotoxicity

R P Gale et al. J Immunol. 1975 Mar.

Abstract

Human polymorphonuclear leukocytes (PMN) lyse antibody-coated target cells in an immunologically specific fashion--antibody-dependent cellular cytotoxicity (ADCC). PMN-mediated cytolysis is independent of complement, de novo protein synthesis, and DNA replication. Cytolysis is rapid, detectable at low PMN:target cell ratios, and exceeds lymphocyte-mediated ADCC. The interaction appears to be mediated via an Fc receptor and is inhibited by aggregated gamma-globulin. A role for PMN in host tumor cell immunity is discussed.

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