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. 1979 Nov 26;29(2):169-71.
doi: 10.1007/BF02408073.

The occurrence of chondroitin-6-sulphate in adult human compact bone tissue

A Hjerpe, F P Reinholt, B Engfeldt

The occurrence of chondroitin-6-sulphate in adult human compact bone tissue

A Hjerpe et al. Calcif Tissue Int. .

Abstract

Compact bone tissue chondroitin sulphate, previously considered to be pure chondroitin-4-sulphate, was isolated from three adult human femoral diaphyses and digested with chondroitinase ABC. Assaying these digests by means of high performance liquid chromatography we could demonstrate that 12 to 14% of the disaccharide residues were 6-sulphated. The 4/6-ratios were also studied in chondroitin sulphate fractions of different molecular size. Slightly increasing amounts of 6-sulphated disaccharides were found with increasing size of the chondroitin sulphates.

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