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. 2001 Nov 19;11(22):2931-4.
doi: 10.1016/s0960-894x(01)00587-x.

Enols as potent antibacterial agents

A Thorarensen  1 , G E Zurenko, M T Sweeney, K R Marotti, T P Boyle
Affiliations

Enols as potent antibacterial agents

A Thorarensen et al. Bioorg Med Chem Lett. .

Abstract

This paper describes the discovery of alpha-trifluoroketoacetamides as potent antibacterial agents against Gram-positive organisms. The initial SAR indicates that the aryl ethyl side chain is essential in maintaining antibacterial activity. The SAR observations have been utilized to design a bioisostere for the alpha-trifluoroketoacetamide with good activity against Gram-positive organisms.

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