Lincomycin-curare interaction

Abstract

After observing a case of lincomycin (LCN)-induced respiratory insufficiency in a patient recovering from d-tubocurarine (DTC) administration, this interaction was studied in cats anesthetized with halothane-nitrous-oxide-oxide-oxygen. The sciatic nerve was stimulated with a 1.6-second tetanci train of 62.5 Hz every 10 seconds. The area under the contraction curve was electronically integrated and recorded. Five control cats received 0.01 mg/kg DTC every 2 minutes until time-tension integral response (TTIR) was zero. Five experimental cats received 10 mg/kg of LCN followed in 10 minutes by 0.01 mg/kg of DTC every 2 minutes until TTIR was zero. Both groups recovered to 50 per cent of control and were given 10 mg/kg of LCN. There was no difference between the slope of the y-intercept of the regression lines for the log-dose response curves for DTC in the two groups. LCN during recovery from DTC had a statist "Intermittent mandatory ventilation in the treatment of patients with chronic obstructive pulmonary disease".