doi: 10.1021/ol016677o.
Rapid access to polyketide scaffolds via vinylogous Mukaiyama aldol reactions
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- PMID: 11678708
- DOI: 10.1021/ol016677o
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Rapid access to polyketide scaffolds via vinylogous Mukaiyama aldol reactions
Org Lett.
.
Abstract
[reaction: see text]. The use of the Z-configured vinylogous silyl ketene acetals in Mukaiyama aldol reactions is described. Isopropyl alcohol as scavanger and the use of tris(pentafluorophenyl)borane as the Lewis acid are required for obtaining the gamma-alkylated syn-product selectively. In cases of alpha-chiral aldehydes, Felkin-Anh selectivity was observed.
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