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. 2001 Jan;1(1):66-9.
doi: 10.1002/1615-9861(200101)1:1<66::AID-PROT66>3.0.CO;2-S.

Single molecule detector for mass spectrometry with mass independent detection efficiency

D Twerenbold  1 , D Gerber, D Gritti, Y Gonin, A Netuschill, F Rossel, D Schenker, J L Vuilleumier
Affiliations

Single molecule detector for mass spectrometry with mass independent detection efficiency

D Twerenbold et al. Proteomics. 2001 Jan.

Abstract

Experimental results from equimolar PEG and protein standards samples are presented from a MALDI-TOF mass spectrometer equipped with both ionizing detectors and the novel single molecule sensitive cryodetectors. The data are consistent with a model hypothesis suggesting that the observed decrease in signal strength in conventional ionizing detector MALDI-TOF mass spectrometers can be explained by the exponentially decreasing quantum efficiency of ionizing detectors. Cryodetectors, in contrast, have a mass independent detection efficiency of 100% on impact and provide additional information on the molecule state owing to the calorimetric nature of the detection mechanism.

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