Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1975 Apr;11(4):754-7.
doi: 10.1128/iai.11.4.754-757.1975.

Evaluation of a live, attenuated recombinant influenza vaccine in high school children

G M Schiff, C C Linnemann Jr, L shea, B Lange, T Rotte
Clinical Trial

Evaluation of a live, attenuated recombinant influenza vaccine in high school children

G M Schiff et al. Infect Immun. 1975 Apr.

Abstract

A live, attenuated, recombinant influenza vaccine (Alice strain) administered intranasally was evaluated in high school students and compared with intranasal placebo and subcutaneous, inactivated, bivalent influenza vaccine. The Alice strain was antigenic, increasing the geometric mean titer (GMT) from a prestudy level of 30.2 to a postvaccine level of 189.6. The inactivated vaccine increased the GMT from 32.9 to 361.8. There was no increase in the GMT among the placebo recipients. The Alice strain produced little reaction. With an antigenic, safe, acceptable, live, attenuated influenza vaccine available, immunization on a widespread basis should be considered.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Am J Hyg. 1958 Sep;68(2):190-212 - PubMed
    1. Adv Intern Med. 1971;17:143-70 - PubMed
    1. Pediatrics. 1973 Sep;52(3):416-9 - PubMed
    1. Med J Aust. 1973 Jun 2;:Suppl:42-7 - PubMed
    1. Med J Aust. 1973 Jun 2;:Suppl:33-8 - PubMed

Publication types