Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2001 Nov;39(11):4190-2.
doi: 10.1128/JCM.39.11.4190-4192.2001.

Determining confidence intervals when measuring genetic diversity and the discriminatory abilities of typing methods for microorganisms

H Grundmann  1 , S Hori, G Tanner
Affiliations

Determining confidence intervals when measuring genetic diversity and the discriminatory abilities of typing methods for microorganisms

H Grundmann et al. J Clin Microbiol. 2001 Nov.

Abstract

We describe here a method for determining confidence intervals for a commonly used index of diversity. This approach facilitates the comparison of the genetic population structure of microorganisms isolated from different environments and improves the objective assessment of the discriminatory power of typing techniques.

PubMed Disclaimer

References

    1. Grundmann, H. J., K. J. Towner, L. Dijkshoorn, P. Gerner-Smidt, M. Maher, H. Seifert, and M. Vaneechoutte. Multicenter study using standardized protocols and reagents for evaluation of reproducibility of PCR-based fingerprinting of Acinetobacter spp. J. Clin. Microbiol. 35:3071–3307. - PMC - PubMed
    1. Hunter P R, Gaston M A. Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. J Clin Microbiol. 1988;26:2465–2466. - PMC - PubMed
    1. Li W H, Graur D. Genetic polymorphisms. In: Li W H, Graur D, editors. Fundamentals of molecular evolution. Sunderland, Mass: Sinauer Associates; 1991. pp. 35–40.
    1. Shannon C E. A mathematical theory of communication. Bell Syst Tech J. 1948;27:376–423. ; 623–656.
    1. Simpson E H. Measurement of diversity. Nature. 1949;163:688.

MeSH terms

Substances