A novel cyclin provides a link between dopamine and RNA processing
- PMID: 11683987
- DOI: 10.1016/s0896-6273(01)00469-x
A novel cyclin provides a link between dopamine and RNA processing
Abstract
Regulation of gene expression by dopamine may play an important role in learning, reward, and addiction. Hyman and colleagues now report the characterization of ania-6, a novel cyclin that associates with RNA polymerase II and is induced by dopamine or cocaine in the neostriatum. Ania-6 may thus provide a link between dopamine and gene expression at the level of mRNA processing.
Comment on
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Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin.Neuron. 2001 Oct 25;32(2):277-87. doi: 10.1016/s0896-6273(01)00465-2. Neuron. 2001. PMID: 11683997
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