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Review
. 2001 Nov;11(11):S27-31.
doi: 10.1016/s0962-8924(01)02151-1.

Cellular senescence as a tumor-suppressor mechanism

J Campisi  1
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Free article
Review

Cellular senescence as a tumor-suppressor mechanism

J Campisi. Trends Cell Biol. 2001 Nov.
Free article

Abstract

Organisms with renewable tissues had to evolve mechanisms to prevent the development of cancer. One such mechanism is cellular senescence, which irreversibly arrests the growth of cells at risk for neoplastic transformation. Recent findings have revealed the complexities of the senescence phenotype and unexpected possible consequences for the organism.

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