Review
doi: 10.1016/s0962-8924(01)02149-3.
Double-strand breaks and tumorigenesis
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- PMID: 11684443
- DOI: 10.1016/s0962-8924(01)02149-3
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Review
Double-strand breaks and tumorigenesis
Trends Cell Biol.
2001 Nov.
Abstract
The establishment of connections between biochemical defects and clinical disease is a major goal of modern molecular genetics. In this review, we examine the current literature that relates defects in the two major DNA double-strand-break repair pathways--homologous recombination and nonhomologous end-joining--with the development of human tumors. Although definitive proof has yet to be obtained, the current literature is highly suggestive of such a link.
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