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Review
. 2001;2(2):71-9.
doi: 10.1186/rr41. Epub 2001 Mar 8.

Th2 cytokines and asthma. The role of interleukin-5 in allergic eosinophilic disease

S Greenfeder  1 , S P Umland, F M Cuss, R W Chapman, R W Egan
Affiliations
Review

Th2 cytokines and asthma. The role of interleukin-5 in allergic eosinophilic disease

S Greenfeder et al. Respir Res. 2001.

Abstract

Interleukin-5 is produced by a number of cell types, and is responsible for the maturation and release of eosinophils in the bone marrow. In humans, interleukin-5 is a very selective cytokine as a result of the restricted expression of the interleukin-5 receptor on eosinophils and basophils. Eosinophils are a prominent feature in the pulmonary inflammation that is associated with allergic airway diseases, suggesting that inhibition of interleukin-5 is a viable treatment. The present review addresses the data that relate interleukin-5 to pulmonary inflammation and function in animal models, and the use of neutralizing anti-interleukin-5 monoclonal antibodies for the treatment of asthma in humans.

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