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Review
. 2001;2(2):90-101.
doi: 10.1186/rr44. Epub 2001 Feb 22.

Role of endothelin-1 in lung disease

K A Fagan  1 , I F McMurtry, D M Rodman
Affiliations
Review

Role of endothelin-1 in lung disease

K A Fagan et al. Respir Res. 2001.

Abstract

Endothelin-1 (ET-1) is a 21 amino acid peptide with diverse biological activity that has been implicated in numerous diseases. ET-1 is a potent mitogen regulator of smooth muscle tone, and inflammatory mediator that may play a key role in diseases of the airways, pulmonary circulation, and inflammatory lung diseases, both acute and chronic. This review will focus on the biology of ET-1 and its role in lung disease.

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Figures

Figure 1
Figure 1
Biosynthesis and amino acid sequence and structure of endothelin-1, endothelin-2, and endothelin-3 and related sarafotoxins. ET-2 and ET-3 differ from ET-1 by two and five amino acids, respectively, while sarafotoxin differs by seven amino acids.
See this image and copyright information in PMC

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