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Review
. 2001;2(3):129-32.
doi: 10.1186/rr48. Epub 2001 Apr 2.

The coming-of-age of the hygiene hypothesis

F D Martinez  1
Affiliations
Review

The coming-of-age of the hygiene hypothesis

F D Martinez. Respir Res. 2001.

Abstract

The hygiene hypothesis, as originally proposed, postulated an inverse relation between the incidence of infectious diseases in early life and the subsequent development of allergies and asthma. New evidence from epidemiological, biological and genetic studies has significantly enlarged the scope of the hypothesis. It now appears probable that environmental 'danger' signals regulate the pattern of immune responses in early life. Microbial burden in general, and not any single acute infectious illness, is the main source of these signals. The latter interact with a sensitive and complex receptor system, and genetic variations in this receptor system may be an important determinant of inherited susceptibility to asthma and allergies.

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References

    1. Woolcock AJ, Peat JK. Evidence for the increase in asthma worldwide. Ciba Found Symp. 1997;206:122–134. - PubMed
    1. Strachan DP. Hay fever, hygiene, and household size. Br Med J. 1989;299:1259–1260. - PMC - PubMed
    1. Martinez FD, Holt PG. Role of microbial burden in aetiology of allergy and asthma. Lancet. 1999;354(suppl 2):SII12–SII15. - PubMed
    1. Strachan DP. Family size, infection and atopy: the first decade of the 'hygiene hypothesis'. Thorax. 2000;55(suppl 1):S2–S10. doi: 10.1136/thorax.55.suppl_1.S2. - DOI - PMC - PubMed
    1. Holt PG, Jones CA. The development of the immune system during pregnancy and early life. Allergy. 2000;55:688–697. doi: 10.1034/j.1398-9995.2000.00118.x. - DOI - PubMed

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