Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2001;2(5):276-9.
doi: 10.1186/rr69. Epub 2001 Aug 7.

Glycosylation and the cystic fibrosis transmembrane conductance regulator

T F Scanlin  1 , M C Glick
Affiliations
Review

Glycosylation and the cystic fibrosis transmembrane conductance regulator

T F Scanlin et al. Respir Res. 2001.

Abstract

The cystic fibrosis transmembrane conductance regulator (CFTR) has been known for the past 11 years to be a membrane glycoprotein with chloride channel activity. Only recently has the glycosylation of CFTR been examined in detail, by O'Riordan et al in Glycobiology. Using cells that overexpress wild-type (wt)CFTR, the presence of polylactosamine was noted on the fully glycosylated form of CFTR. In the present commentary the results of that work are discussed in relation to the glycosylation phenotype of cystic fibrosis (CF), and the cellular localization and processing of DeltaF508 CFTR. The significance of the glycosylation will be known when endogenous CFTR from primary human tissue is examined.

PubMed Disclaimer

References

    1. Riordan JR, Rommens JM, Kerem B, Alon M, Rozmahel R, Grzelczak Z, Zielenski J, Lok S, Plavsic N, Chou JL, Drumm ML, Iannuzzi MC, Collins FS, Tsui LC. Identification of the cystic fibrosis gene: cloning and characterization of the complementary DNA. Science. 1989;245:1066–1073. - PubMed
    1. Scanlin TF, Glick MC. Terminal glycosylation in cystic fibrosis. Biochim Biophys Acta. 1999;1455:241–253. doi: 10.1016/S0925-4439(99)00059-9. - DOI - PubMed
    1. Alper J. Carbohydrates and glycobiology. Science. 2001;291:2337–2378. doi: 10.1126/science.291.5512.2337. - DOI
    1. Gregory RJ, Cheng SH, Rich DP, Marshall J, Paul S, Hehir K, Ostedgaard L, Welsh MJ, Smith AE. Expression and characterization of the cystic fibrosis transmembrane conductance regulator. Nature. 1990;347:382–386. doi: 10.1038/347382a0. - DOI - PubMed
    1. Cheng SH, Gregory RJ, Marshall J, Paul S, Souza DW, White GA, O'Riordan CR, Smith AE. Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis. Cell. 1990;63:827–834. - PubMed

Publication types

MeSH terms

Substances