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. 2001;2001(4):CD002155.
doi: 10.1002/14651858.CD002155.

Long-acting beta-2-agonists for bronchiectasis

A Sheikh  1 , D Nolan, M Greenstone
Affiliations

Long-acting beta-2-agonists for bronchiectasis

A Sheikh et al. Cochrane Database Syst Rev. 2001.

Abstract

Background: Symptoms of bronchiectasis include chronic productive cough, wheeze, breathlessness and recurrent infections of the lower respiratory tract. Long-acting bronchodilators are being used more frequently in the management of people with this condition.

Objectives: To determine the effectiveness of long-acting bronchodilators in the management of bronchiectasis that is not due to cystic fibrosis.

Search strategy: We searched the Cochrane Airways Group Bronchiectasis Database made up of trials identified from searching the Cochrane Controlled Trials Register, MEDLINE, EMBASE and hand-searches of leading respiratory journals. The latest searches were performed in May 2001.

Selection criteria: Randomised controlled trials, with or without masking.

Data collection and analysis: The results of searches were reviewed against pre-specified criteria.

Main results: We were unable to identify any randomised controlled trials investigating the effectiveness of long-acting bronchodilator therapy in the management of bronchiectasis.

Reviewer's conclusions: Further research is needed to establish if long-acting bronchodilators have a role in the management of people with bronchiectasis.

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Conflict of interest statement

None known.

References

References to studies excluded from this review

De Lunca 1999 {published data only}
    1. Lunca N, Capuzi P, D'Angeli AL, D'Antoni L, Pavone P, Santis M, et al. High resolution computed tomography assessment of beta 2‐agonist induced bronchodilation in chronic obstructive pulmonary disease patients. European Review for Medical and Pharmocological Sciences 1999;3(2):83‐7. - PubMed
Weiss 1982 {published data only}
    1. Weiss JW, McFadden ER, Ingram RH. Bronchodilatation, lung recoil, and density dependence of maximal expiratory flow. Journal of Applied Physiology 1982;52(4):874‐8. - PubMed

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