doi: 10.1038/ng754.
Assembly of microarrays for genome-wide measurement of DNA copy number
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- PMID: 11687795
- DOI: 10.1038/ng754
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Assembly of microarrays for genome-wide measurement of DNA copy number
Nat Genet.
2001 Nov.
Abstract
We have assembled arrays of approximately 2,400 BAC clones for measurement of DNA copy number across the human genome. The arrays provide precise measurement (s.d. of log2 ratios=0.05-0.10) in cell lines and clinical material, so that we can reliably detect and quantify high-level amplifications and single-copy alterations in diploid, polyploid and heterogeneous backgrounds.
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