Signs of asphyxia at birth and risk of schizophrenia. Population-based case-control study
- PMID: 11689395
- DOI: 10.1192/bjp.179.5.403
Signs of asphyxia at birth and risk of schizophrenia. Population-based case-control study
Abstract
Background: Previous research has found an association between obstetric complications and schizophrenia, but in many studies the sample size was limited, and no assessment of specific exposures was possible.
Aims: To assess the role of different complications, and in particular to distinguish between disordered foetal development and hypoxia at birth.
Method: From the Stockholm County In-Patient Register and community registers, we identified 524 cases of schizophrenia and 1043 controls, matched for age, gender, hospital and parish of birth. Data on obstetric complications were obtained from birth records.
Results: There was a strong association between signs of asphyxia at birth and schizophrenia (OR 4.4; 95% C11.9-10.3) after adjustment for other obstetric complications, maternal history of psychotic illness and social class.
Conclusions: Signs of asphyxia at birth are associated with an increased risk of schizophrenia in adults.
Comment in
-
Invited commentaries on: Signs of asphyxia at birth and risk of schizophrenia/Obstetric complications and risk of schizophrenia.Br J Psychiatry. 2001 Nov;179:415-6. doi: 10.1192/bjp.179.5.415. Br J Psychiatry. 2001. PMID: 11689397 No abstract available.
-
Asphyxia at birth and schizophrenia.Br J Psychiatry. 2002 May;180:465. doi: 10.1192/bjp.180.5.465. Br J Psychiatry. 2002. PMID: 11983647 No abstract available.
Similar articles
-
Obstetric complications and risk of schizophrenia. Effect of gender, age at diagnosis and maternal history of psychosis.Br J Psychiatry. 2001 Nov;179:409-14. doi: 10.1192/bjp.179.5.409. Br J Psychiatry. 2001. PMID: 11689396
-
Obstetric conditions and risk of first admission with schizophrenia: a Danish national register based study.Schizophr Res. 2007 Dec;97(1-3):51-9. doi: 10.1016/j.schres.2007.07.018. Epub 2007 Aug 31. Schizophr Res. 2007. PMID: 17764905
-
Invited commentaries on: Signs of asphyxia at birth and risk of schizophrenia/Obstetric complications and risk of schizophrenia.Br J Psychiatry. 2001 Nov;179:416. doi: 10.1192/bjp.179.5.416. Br J Psychiatry. 2001. PMID: 11689398 No abstract available.
-
Gestational and neonatal factors in the etiology of schizophrenia.J Clin Psychol. 1993 May;49(3):447-56. doi: 10.1002/1097-4679(199305)49:3<447::aid-jclp2270490321>3.0.co;2-4. J Clin Psychol. 1993. PMID: 8315050 Review.
-
[Do obstetric complications increase the risk of schizophrenia?].Tidsskr Nor Laegeforen. 2010 Feb 11;130(3):270-2. doi: 10.4045/tidsskr.09.0699. Tidsskr Nor Laegeforen. 2010. PMID: 20160770 Review. Norwegian.
Cited by
-
Non-injurious neonatal hypoxia confers resistance to brain senescence in aged male rats.PLoS One. 2012;7(11):e48828. doi: 10.1371/journal.pone.0048828. Epub 2012 Nov 16. PLoS One. 2012. PMID: 23173039 Free PMC article.
-
Predicting novel genomic regions linked to genetic disorders using GWAS and chromosome conformation data - a case study of schizophrenia.Sci Rep. 2019 Nov 29;9(1):17940. doi: 10.1038/s41598-019-54514-2. Sci Rep. 2019. PMID: 31784692 Free PMC article.
-
Differential expression of presynaptic genes in a rat model of postnatal hypoxia: relevance to schizophrenia.Eur Arch Psychiatry Clin Neurosci. 2010 Nov;260 Suppl 2(Suppl 2):S81-9. doi: 10.1007/s00406-010-0159-1. Epub 2010 Oct 14. Eur Arch Psychiatry Clin Neurosci. 2010. PMID: 20945070 Free PMC article.
-
RHD maternal-fetal genotype incompatibility increases schizophrenia susceptibility.Am J Hum Genet. 2002 Dec;71(6):1312-9. doi: 10.1086/344659. Epub 2002 Nov 18. Am J Hum Genet. 2002. PMID: 12439825 Free PMC article.
-
A plausible model of schizophrenia must incorporate psychological and social, as well as neuro developmental, risk factors.Dialogues Clin Neurosci. 2001 Dec;3(4):243-56. doi: 10.31887/DCNS.2001.3.4/ebramon. Dialogues Clin Neurosci. 2001. PMID: 22033679 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical